bjack on 15/3/2020 at 19:35
Nickie, you touched my heart with your last post. I am humbled.
Renzatic on 15/3/2020 at 19:38
What Bjack said. We need more Nickies in this world.
Tocky on 15/3/2020 at 20:56
Quote Posted by Gryzemuis
I read the column you linked.
Then you did way more than Tony ever does. I used to do that. Now I, like everyone else, just assume the things he posts are unsubstantiated posits based on articles which prove his assertions wrong.
It would appear that is the right wing way. They never expect anyone to read because they never do.
Also it is good to see GBM has yet to contract rabies.
Renzatic on 15/3/2020 at 20:57
Wait. What? I thought GBM always had rabies.
Tocky on 15/3/2020 at 21:03
A common misconception as he is known to eat the hearts of woodland creatures while still beating.
zombe on 15/3/2020 at 22:23
The situation in Italy is very troubling and puzzling - especially comparing to S. Korea.
Korea [1]: 7194(~88%)=mild, 59(~1%)=serious, 834(~10%)=recovered, 75(~1%)=dead
Italia [2]: 18931(~76%)=mild, 1672(~7%)=serious, 2335(~9%)=recovered, 1809(7%)=dead
Without rounding, that is a consistent 8-9 times higher trouble case rate (both of the open and closed variants). This is especially troubling as Korea is recovering and it seems the trouble cases linger the most making the tail especially deadly in stats.
I hope this is explained by the extensive testing done in Korea (ie. ends up finding and counting even the mildest of cases). I hope the difference in stats is from self imposed home quarantine or something to the effect.
Because...
Alternate explanation is that the European strains are already somehow nastier [3] (note that while the mutation tree is, obviously, on strong standing - exact location and time are not - duh). Korea and China strains are in the same pot - so, cannot say where Korea one has went. If we got something nastier - that would suck. So far - i doubt any of that has happened (most mutation do bugger all). PS. i would like the mutations to stay away from the "S" section (see in [3]) as that is what builds the spiky shell - it is needed for an effective vaccine. Which, of course, is being worked on.
Third explanation (that does not make much sense either):
TL;DR Italy somewhy does not use the recommended scientifically unproven treatments Korea uses - or there is some unexpected divergence of the presumed effect due to who-knows-what.
First, COVID-19 (aka SARS-CoV-2) workings, 101:
Normal:
* cell nucleus sends out some thingamabob where it gets capped at both ends with some distinct delimiters.
* using thous delimiters some other stuff recognizes the thing and uses it to produce some proteins to do what needs to be done.
Hijack:
* virus breaks into the cell and drops its strain - that also has the correct caps.
* the cells legit stuff cannot tell the difference and produces what the virus strain tells to.
* what gets produces is what actually does the replication of the virus.
It is known that Zink messes that last part up really-really good. Why or how that happens is unknown, but that it does it is well known for many years [4]. Unfortunately, our body regulates Zink and - moreover - it is an ion (Zn2+) and therefore cannot pass cell membrane. Unless you got something to facilitate that passing - aka. a zink ionophore. There are quite a few things known that can do it. And they work ... in vitro [5]. That would be an huge help for troubled cases as if would pause the attack and give the body time to figure it out and defeat it.
Since that stuff is known to work and has been used for years prior for other stuff - ie. side-effects known etc. Then it makes sense to use thous treatments. Sure. It should work, but does it? In vitro does not tell the whole story and the rest of the science is not yet in. Still worth doing. At least Korea thought so and gives recommendations to others to do the same [6].
So, what does Italy do? Is there something different?
Forth: health care system has collapsed. Erm ... no. Not anywhere to the degree it seems to be needed - not yet anyway.
Fifth: any or all of the above.
--------------------------
[1] (
https://www.worldometers.info/coronavirus/country/south-korea/)
[2] (
https://www.worldometers.info/coronavirus/country/italy/)
[3] (
https://nextstrain.org/ncov)
[4] (
https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1001176)
[5] (
https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciaa237/5801998)
[6] (
http://www.koreabiomed.com/news/articleView.html?idxno=7428)
--------------------------
PS1. In case anyone gets some funny ideas (there are multiple alternate treatment sets and i know at least one that has all components available over the counter, no prescriptions needed ... easy to find out too) - self medicating is a bad idea. We are talking messing with ions here - there are combinations of thous treatments known to me that clash (luckily, i think most of it is prescription only ... AFAIK) - known to cause arrhythmia and death. If you doc does not know you have messed with one - he might just accidentally/legitimately kill you with the other. Also, it obviously just hinders/delays the virus - which is useless if your body is not already fighting it. You kind of need to get sufficiently sick first.
PS2. I am incompetent in everything covered in this post.
Harvester on 15/3/2020 at 22:23
My company has decided that everyone works from home until at least the end of the month. Good call in my opinion, I will make sure to keep productivity up to normal standards in return for their responsible decision. I'm not going to do any personal stuff during work hours (and vice versa).
The Netherlands are closing pre-schools and schools, bars/restaurants and sports facilities. All leaves are suspended for health care workers. I've seen footage from Spain which is much more in lockdown, and both cashiers and customers at the supermarkets wear mouth pieces. I suspect it's the same in Italy. I'd consider wearing them when I go to the supermarket, but I wouldn't know where to even get any. I have ordered light leather gloves online for going outside so nothing touches my hands outside and at the supermarket. Don't know if it makes much of a difference, but you never know. Maybe disposable gloves are better, but again, don't know where to get them.
These are strange times, even my parents who are in their 70's admit to never having been through something like this. Take care and stay safe everyone!
jkcerda on 15/3/2020 at 22:41
Quote Posted by Renzatic
I got rid of DirectTV awhile ago. These days, I'm all about the antenna, Netflix, and Hulu (and occasionally Amazon). All the movies and TV I want, for a 3rd of the price.
Yes. Yes it is.
tenchisTV. love it at $13.
Nickie. keeping it to the numbers just to try and keep the panic down a bit, I am well aware those numbers are loved ones to many and this is affecting them greatly.
