Azaran on 13/7/2022 at 17:19
(
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8953947/) A combo of Rhodiola, Eleutherococcus, and Schisandra herbs appears to be helpful against Long Covid
Quote:
The number of patients with lack of fatigue and pain symptoms was significantly less in the Chisan® treatment group than in the placebo group on Days 9 (39% vs. 57%, pain relief, p = 0.0019) and 11 (28% vs. 43%, relief of fatigue, * p = 0.0157). Significant relief of severity of all Long COVID symptoms over the time of treatment and the follow-up period was observed in both groups of patients, notably decreasing the level of anxiety and depression from mild and moderate to normal, as well as increasing cognitive performance in patients in the d2 test for attention and increasing their physical activity and workout (daily walk time). However, the significant difference between placebo and Chisan® treatment was observed only with a workout (daily walk time) and relieving respiratory insufficiency (cough). A clinical assessment of blood markers of the inflammatory response (C-reactive protein) and blood coagulation (D-dimer) did not reveal any significant difference over time between treatment groups except significantly lower IL-6 in the Chisan® treatment group. Furthermore, a significant difference between the placebo and Chisan® treatment was observed for creatinine: Chisan® significantly decreased blood creatinine compared to the placebo, suggesting prevention of renal failure progression in Long COVID. In this study, we, for the first time, demonstrate that adaptogens can increase physical performance in Long COVID and reduce the duration of fatigue and chronic pain. It also suggests that Chisan®/ADAPT-232 might be useful for preventing the progression of renal failure associated with increasing creatinine.
Quote:
The active ingredients of Chisan®/ADAPT-232 are extracts from Rhodiola rosea roots, Schisandra chinensis berry, and Eleutherococcus senticosus root with adaptogenic, stimulating, and stress-protective activities [40,41,42]. The combination of these ingredients synergistically contributes to the efficacy of Chisan®/ADAPT-232.
Azaran on 22/7/2022 at 20:07
(
https://www.proactiveinvestors.ca/companies/news/983880/todos-medical-says-dietary-supplement-tollovid-has-beneficial-effect-in-long-covid-case-study-after-26-days-983880.html) Another herbal supplement showing potential. If the Amazon (
https://www.amazon.com/Tollovid-Maximum-Protection-Natural-Supplement/dp/B09G7VFB58) reviews are legit, this could be the smoking gun
Quote:
Todos Medical Ltd majority-owned subsidiary 3CL Pharma Ltd has reported a Day 26 update from an ongoing 60-day case study of the dietary supplement 3CL protease inhibitor Tollovid in a patient experiencing symptoms of long COVID.
The patient, a 33-year-old man, originally contracted COVID-19 in March 2021 and experienced persistent long COVID symptoms, including significant weight loss, nausea and fatigue, the company said.
On May 5, he began a regimen of 12 Tollovid Maximum Strength capsules for five days, and symptoms significantly improved. Digestion and heart rate returned to the patient's pre-COVID baseline and he reported improvements in brain fog as well as better sleep, although a sleep monitor still noted less sleep.
READ: Todos Medical updates investors on its lab Provista Diagnostics, its 3CL Pharma subsidiary, and its plans to uplist onto a major stock exchange
During the three weeks since the patient last took Tollovid, the patient reported maintenance of most of the gains after restarting treatment with pravastatin (10mg daily), low dose aspirin daily, and fluvoxamine (25mg daily) treatment regimen. The patient intends to restart Tollovid over a 10-day period in the near future to determine whether Tollovid can further improve his symptoms and whether those gains are subsequently maintained, the company said.
Tollovid is a dietary supplement that inhibits the enzyme 3CL protease, which is the main protease found in COVID-19.
“Prior to taking Tollovid, my flare-ups were an eight out of 10,” on the severity of symptoms scale, with zero being no symptoms at all and 10 being the worst possible symptoms, the patient said. “After taking Tollovid, [three capsules, four times per day for five days,] my flare-ups are less intense with a rating of only three out of 10. Because of Tollovid, I am suffering less now.”
This case study shows Tollovid had a beneficial effect, the company said. Treatments prior to Tollovid alleviated some symptoms and provided relief, the company noted, but didn't address the elevated heart rate which underpins other symptoms such as the head concussed feeling.
Whatever mechanism was addressed by inhibiting 3CL protease was likely responsible for the reduction in heart rate to baseline levels, the company added. The elimination of digestion issues further enhances the theory of viral persistence in reservoirs located in the gastrointestinal tract. The lack of deep sleep measured by the sleep monitor should be noted, Todos acknowledged.
demagogue on 23/7/2022 at 01:14
I haven't taken all that many science classes but even I know Amazon reviews will have a sample bias problem, and "a patient" doesn't carry much statistical significance. The study above that looks more promising if the studies were well conducted. Long covid is such a mixed bag in so many nuanced ways though. Disautonomia is a term that keeps coming up a lot.
I like that someone mentions the "head concussed" feeling though. That was one of the absolute worst parts for me. A fast heart rate by itself is no problem, but feeling like you're going to have a stroke is very scary, and I think this is the first time I've even seen it mentioned elsewhere. My cardiologist would keep trying to disagree with me. I was scared to death going through spells, especially when it hits the droopy sleepy level of concussion like it does for the first 2 waves or so, and for that matter, it came in precisely timed 15-minute waves over a 2~3 hour period for me, so there was definitely method to its madness. But then she'd say something like "no you shouldn't be feeling anything with your head." She couldn't even guess what I was talking about. "It's just a rapid heartbeat. No different than just exercising." But it was a lot different than just exercising!!
faetal on 24/7/2022 at 20:00
Lots of repetition of the product name too.
Reads like an ad.
Plus no mention of a mechanism of action.
faetal on 25/7/2022 at 23:00
This is direct from Researchgate - it hasn't undergone any peer review that I can tell.
Its first suggestion is Ivermectin, so I would immediately be looking for some solid validation.
The authors' publication history is a sea of red flags too. Check out the number of publications and the absence of other authors on the majority of the COVID-relevant stuff.
We don't need everything we can get, we need everything which has some kind of beneficial impact and doesn't clog the information airwaves.
mxleader on 26/7/2022 at 03:23
Covid has been running amuck through my office and everyone has had two or more vaccinations. I came down with symptoms on July 4th and it wasn't terrible but it sure wasn't fun and I still have a lingering cough. I started PAXLOVID right away and maybe it helped but I have no idea really.
faetal on 26/7/2022 at 22:41
Quote Posted by mxleader
Covid has been running amuck through my office and everyone has had two or more vaccinations. I came down with symptoms on July 4th and it wasn't terrible but it sure wasn't fun and I still have a lingering cough. I started PAXLOVID right away and maybe it helped but I have no idea really.
It may have done - it is an antiviral with a defined mechanism of action: (
https://www.ema.europa.eu/en/medicines/human/EPAR/paxlovid)
mxleader on 27/7/2022 at 01:47
It's interesting, and makes sense, that one of the medications in the paxlovid five day dosage is also one used in HIV therapy.
Azaran on 1/8/2022 at 17:41
(
https://www.massgeneral.org/news/press-release/diabetes-in-patients-with-covid-may-simply-be-transitory#:~:text=A%20new%20study%20shows%20that,used%20insulin%20after%20one%20year.) Some possible good news about long/severe covid-induced diabetes
Quote:
A new study shows that blood sugar levels of COVID-19 patients newly diagnosed with diabetes during hospital admission often returned to normal following discharge, and that only eight percent used insulin after one year.
COVID-19 patients with newly diagnosed diabetes were more likely to be younger, non-White, and uninsured or on Medicaid, suggesting these may be cases of pre-existing but undiagnosed diabetes in people with limited access to healthcare services.
Rather than causing a new form of diabetes, the inflammatory stress of COVID-19 may push people with pre-diabetes past the blood sugar threshold for diabetes diagnosis.
Quote:
For its study, the MGH team looked at 594 individuals who exhibited signs of diabetes mellitus when admitted to MGH at the height of the pandemic in the spring of 2020. Of that group, 78 had no known diagnosis of diabetes prior to admission. Researchers learned that many of these newly diagnosed patients -- versus those with pre-existing diabetes -- had less severe blood sugar levels but more severe COVID-19.
Follow-up with this cohort after hospital discharge revealed that roughly half its members reverted to normal blood sugar levels and that only eight percent required insulin after one year.“This suggests to us that newly diagnosed diabetes may be a transitory condition related to the acute stress of COVID-19 infection,” explains Cromer. Indeed, this key finding supports the clinical argument that newly diagnosed diabetes is likely caused by insulin resistance -- the inability of cells to properly absorb blood sugar in response to insulin, resulting in higher-than- normal build-up of glucose in the blood - rather than by insulin deficiency, caused by direct and permanent injury to the beta cells which manufacture insulin.
“Our results suggest that acute insulin resistance is the major mechanism underlying newly diagnosed diabetes in most patients with COVID-19, and that insulin deficiency, if it occurs at all, is generally not permanent,” says Cromer. “These patients may only need insulin or other medications for a short time, and it's therefore critical that physicians closely follow them to see if and when their conditions improve.”